肝炎
Multifaceted therapeutic benefits of factors derived from stem cells from human exfoliated deciduous teeth for acute liver failure in rats.
Matsushita Y, Ishigami M, Matsubara K, Kondo M, Wakayama H, Goto H,Ueda M, Yamamoto A.J Tissue Eng Regen Med. 2015 Sep doi: 10.1002/term.2086

関節リウマチ
Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental rheumatoid arthritis.
Ishikawa J, Takahashi N, Matsumoto T, Yoshioka Y, Yamamoto N, Nishikawa M, Hibi H, Ishigro N,Ueda M,Furukawa K, Yamamoto A.Bone. 2015 Nov 19;83:210-219. doi: 10.1016/j.bone.2015.11.012. [Epub ahead of print]

心臓疾患
Dental pulp-derived stem cell conditioned medium reduces cardiac injury following ischemia-reperfusion.
Yamaguchi S, Shibata R, Yamamoto N, Nishikawa M, Hibi H, Tanigawa T, Ueda M, Murohara T, Yamamoto A.
Sci Rep. 2015 Nov 6;5:16295. doi: 10.1038/srep16295.

糖尿病
Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic β-cell function.
Izumoto-Akita T, Tsunekawa S, Yamamoto A, Uenishi E, Ishikawa K, Ogata H, Iida A, Ikeniwa M, Hosokawa K,
Niwa Y, Maekawa R, Yamauchi Y, Seino Y, Hamada Y, Hibi H, Arima H, Ueda M, Oiso Y.
BMJ Open Diabetes Res Care. 2015 Oct 19;3(1):e000128. doi: 10.1136/bmjdrc-2015-000128. eCollection 2015.

腎障害
Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury.
Hattori Y, Kim H, Tsuboi N, Yamamoto A, Akiyama S, Shi Y, Katsuno T, Kosugi T, Ueda M, Matsuo S, Maruyama
S.
PLoS One. 2015 Oct 28;10(10):e0140121. doi: 10.1371/journal.pone.0140121. eCollection 2015.

肺障害
Factors secreted from dental pulp stem cells show multifaceted benefits for treating acute lung injury in mice.
Wakayama H, Hashimoto N, Matsushita Y, Matsubara K, Yamamoto N, Hasegawa Y, Ueda M, Yamamoto A.
Cytotherapy. 2015 Aug;17(8):1119-29. doi: 10.1016/j.jcyt.2015.04.009. Epub 2015 May 29.

アルツハイマー病
Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer’s disease.
Mita T, Furukawa-Hibi Y, Takeuchi H, Hattori H, Yamada K, Hibi H, Ueda M, Yamamoto A.
Behav Brain Res. 2015 Jul 22;293:189-197. doi: 10.1016/j.bbr.2015.07.043. [Epub ahead of print]

脳梗塞
Stem cells from human exfoliated deciduous tooth-derived conditioned medium enhance recovery of focal cerebral ischemia in rats.
Inoue T, Sugiyama M, Hattori H, Wakita H, Wakabayashi T, Ueda M.
Tissue Eng Part A. 2013 Jan;19(1-2):24-9. doi: 10.1089/ten.TEA.2011.0385. Epub 2012 Oct 10.

歯周疾患
Secretomes from bone marrow-derived mesenchymal stromal cells enhance periodontal tissue regeneration.
Kawai T, Katagiri W, Osugi M, Sugimura Y, Hibi H, Ueda M.
Cytotherapy. 2015 Apr;17(4):369-81. doi: 10.1016/j.jcyt.2014.11.009. Epub 2015 Jan 14.

Novel application of stem cell-derived factors for periodontal regeneration.
Inukai T, Katagiri W, Yoshimi R, Osugi M, Kawai T, Hibi H, Ueda M.
Biochem Biophys Res Commun. 2013 Jan 11;430(2):763-8. doi: 10.1016/j.bbrc.2012.11.074. Epub 2012 Dec 1.

低酸素脳症
Human dental pulp-derived stem cells protect against hypoxic-ischemic brain injury in neonatal mice.
Yamagata M, Yamamoto A, Kako E, Kaneko N, Matsubara K, Sakai K, Sawamoto K, Ueda M.
Stroke. 2013 Feb;44(2):551-4. doi: 10.1161/STROKEAHA.112.676759. Epub 2012 Dec 13.

脊髄損傷
Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity.
Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, Hashimoto N, Imagama S, Ishiguro N,
Suzumura A, Ueda M, Furukawa K, Yamamoto A.
J Neurosci. 2015 Feb 11;35(6):2452-64. doi: 10.1523/JNEUROSCI.4088-14.2015.

Multifaceted neuro-regenerative activities of human dental pulp stem cells for functional recovery after spinal cord injury.
Yamamoto A, Sakai K, Matsubara K, Kano F, Ueda M.
Neurosci Res. 2014 Jan;78:16-20. doi: 10.1016/j.neures.2013.10.010. Epub 2013 Nov 16. Review.

Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms.
Sakai K, Yamamoto A, Matsubara K, Nakamura S, Naruse M, Yamagata M, Sakamoto K, Tauchi R, Wakao N,
Imagama S, Hibi H, Kadomatsu K, Ishiguro N, Ueda M.
J Clin Invest. 2012 Jan;122(1):80-90. doi: 10.1172/JCI59251. Epub 2011 Dec 1.

骨系疾患
Conditioned media from mesenchymal stem cells enhanced bone regeneration in rat calvarial bone defects.
Osugi M, Katagiri W, Yoshimi R, Inukai T, Hibi H, Ueda M.
Tissue Eng Part A. 2012 Jul;18(13-14):1479-89. doi: 10.1089/ten.TEA.2011.0325. Epub 2012 Jun 12.

Novel cell-free regeneration of bone using stem cell-derived growth factors.
Katagiri W, Osugi M, Kawai T, Ueda M.
Int J Oral Maxillofac Implants. 2013 Jul-Aug;28(4):1009-16. doi: 10.11607/jomi.3036.

Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model.
Ogata K, Katagiri W, Osugi M, Kawai T, Sugimura Y, Hibi H, Nakamura S, Ueda M.
Bone. 2015 May;74:95-105. doi: 10.1016/j.bone.2015.01.011. Epub 2015 Jan 19.

Stem cell-conditioned medium accelerates distraction osteogenesis through multiple regenerative mechanisms.
Ando Y, Matsubara K, Ishikawa J, Fujio M, Shohara R, Hibi H, Ueda M, Yamamoto A.
Bone. 2014 Apr;61:82-90. doi: 10.1016/j.bone.2013.12.029. Epub 2014 Jan 2.

A new application of cell-free bone regeneration: immobilizing stem cells from human exfoliated deciduous teethconditioned medium onto titanium implants using atmospheric pressure plasma treatment.
Omori M, Tsuchiya S, Hara K, Kuroda K, Hibi H, Okido M, Ueda M.
Stem Cell Res Ther. 2015 Jun 19;6:124. doi: 10.1186/s13287-015-0114-1.

皮膚疾患
Mesenchymal stromal cells of human umbilical cord Wharton’s jelly accelerate wound healing by paracrine mechanisms.
Shohara R, Yamamoto A, Takikawa S, Iwase A, Hibi H, Kikkawa F, Ueda M.
Cytotherapy. 2012 Nov;14(10):1171-81. doi: 10.3109/14653249.2012.706705. Epub 2012 Aug 17.

Cell-Based Cytokine Therapy for Skin Rejuvenation.
Minoru Ueda, DDS, PhD, and Yudai Nishino, DDS
The Journal of Craniofacial Surgery & Volume 21, Number 6, November 2010