Restorative Medicine

The key to supporting the ‘Age of 100 for Humanity’ lies in regenerative medicine using ‘SGF’

With increasing average lifespans, the concept of the ‘Age of 100 for Humanity’ has emerged. To maintain a healthy and vibrant state both physically and mentally beyond the age of 100, it is essential to keep cells youthful and functioning optimally. Fulfilling the wish of many to rejuvenate aging cells, ‘SGF (Supernatant of Dental Pulp Stem Cell Cultures)’ makes this possible.

SGF (Supernatant of Dental Pulp Stem Cell Cultures)

SGF (SOLARIA Growth Factor) is the supernatant of dental pulp stem cell cultures developed by Dr. Koshitsugu Koga, a medical doctor. Stem cells from the dental pulp of deciduous teeth, ranging from ages 8 to 12, are cultured. After aspirating and washing the culture medium, a recovery culture medium is added. After 48 hours, cells are removed using a dedicated filter, and the preparation is completed after confirming under a microscope that no cells are present.

SGF, which contains many bioactive substances such as cytokines and exosomes

SGF contains a variety of bioactive substances, including:

  • Cytokines, proteins secreted by cells of the immune system responsible for non-specific communication to target cells.
  • Chemokines, a subgroup of cytokines that act through G protein-coupled receptors to exert their effects.
  • Growth factors, endogenous proteins that stimulate the proliferation and differentiation of specific cells in the body.
  • Exosomes, which facilitate communication between distant cells or tissues, mediate adaptive immune responses, participate in tissue repair, nerve transmission, and transport pathogenic proteins.

With the functions of these substances, regenerative medicine, anti-aging medicine, and aesthetic medicine can now be performed more precisely and smoothly than before.

SGF to complement the limitations of stem cell transplantation

Conventionally, stem cell transplantation has been the mainstay of regenerative medicine and has been supported by many medical institutions. However, it cannot be denied that there are limitations to its widespread use, such as the tendency for tumor formation during the transplantation process, the risk of cancer development, and issues regarding standardization, administration methods, preservation, and cultivation methods, among others. Additionally, the cost associated with stem cell transplantation is high.

In contrast, SGF has features that excel in both safety and effectiveness. By manufacturing and conducting component analysis in advance, standardized products of consistent quality can be used. This allows for high-quality mass production at a lower cost.

SGF, which resolves the problems faced by stem cell transplantation and further enhances efficiency and effectiveness, is poised to become a pivotal factor in the transition phase of regenerative medicine.

Expected Effects of SGF

By utilizing SGF in regenerative medicine:

  • Regenerative medicine
  • Anti-aging medicine
  • Aesthetic medicine

significant benefits are anticipated to be realized.

Restorative Medicine

SGF (Deciduous Tooth Pulp Stem Cell Culture Medium) contains over hundreds of bioactive substances. Therefore, when SGF is administered via intravenous drip or nasal spray, liquid factors including exosomes exhibit paracrine effects, which can lead to a reduction in the risk of onset and recovery for many diseases.

By utilizing SGF:

  • Enhancement of frontal lobe function and cognitive function
  • Strengthening of vascular endothelial cell function
  • Improvement of testicular function

Such effects have been observed as case examples.

Impact of SGF Administration on Telomeres

The major reason why SGF is effectively utilized in restorative medicine and aesthetic medicine lies in the “telomeres”. Telomeres are structures located at the ends of our chromosomes, serving the dual role of protecting the chromosomes and copying them during cell division.

Research by Nobel Prize-winning biologist Dr. Blackburn and others has revealed that this structure is a key element in determining human lifespan and aging. Telomeres shorten as cells divide repeatedly. As telomeres shorten, cells enter a state of aging, making them more susceptible to disease. This aging process is also visible in the form of wrinkles, dark spots, and sagging skin.

It has been discovered that SGF therapy has telomere shortening suppression and elongation effects. This is due to the action of bioactive substances contained in SGF, which promote cellular activation.

Results have shown that continuous SGF administration therapy of 40 milliliters per month, over both short and long periods, leads to a decrease in the numerical value of “telomere age”, which tends to increase with aging.

Anti-Aging Medicine

SGF has been found to be useful in improving concerns commonly faced by men as a means of anti-aging medicine. “Erectile dysfunction (ED)” and “Androgenetic alopecia (AGA)” are examples of concerns where the effects of SGF can be expected.

Treatment of ED with SGF

In conventional ED treatment, substances that promote erection act on vascular endothelial cells. However, if there is deterioration in the function of these cells, secretion of the substance does not occur. SGF has the ability to normalize the function of vascular endothelial cells, thereby promoting improvement in symptoms without the use of medication.

Treatment of AGA with SGF

SGF is directly injected into the scalp to stimulate hair follicle cells, enhance hair growth function, and regulate the hair growth cycle. It also normalizes the function of transporting nutrients needed for hair, restores the hair cycle to a long-term state rather than a temporary one, and maintains healthy hair.

Among the various examination methods, the method that our clinic is particularly focusing on is the “telomere test”.

Telomeres are parts located at the ends of chromosomes that affect aging, lifespan, and genetic strength. The longer they are, the better the health span is maintained, but unfortunately, they shorten every time cells divide. Additionally, as telomeres shorten, the risk of age-related diseases and aging increases.

By introducing SGF treatment, it is possible to address these issues. However, to confirm whether this has been achieved, it is necessary to examine the state of telomeres with specific numerical values. Therefore, by using telomere tests, it becomes possible to examine the state of aging, genetic fatigue, genetic age, and visualize the results of SGF treatment.

 

Utilizing Examination Equipment According to Purpose

In addition to telomere testing, our clinic provides various examination equipment tailored to different purposes.

For treatments targeting diseases such as diabetes, blood tests are conducted. The purpose of this is to quantify whether there have been changes in blood sugar levels due to SGF treatment. We have also introduced examination equipment such as the “LOX-index” for evaluating the risk of stroke and myocardial infarction, and the “MCI (Mild Cognitive Impairment) Screening Test” for early detection of Alzheimer’s disease.

With advanced treatment methods and a variety of examination equipment, we are able to provide the quality, safety, and results of SGF treatment in an appropriate manner.